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Mother' do you trust our Governments? = (COVID-19)
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#31 (permalink)      2/27/2020 9:40:54 PM US Central   quote/reply + tips
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etcetera
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A condition involving immune system dysfunction known as a "cytokine storm" occurred in some of these very ill patients, but it's not yet clear how the new virus affects the immune system, the researchers said.

https://www.usnews.com/news/health-news/articles/2020-01-24/first-clinical-studies-find-wuhan-virus-closely-resembles-sars



Very good not-copyable article about cytokine storms. It was interesting to learn that the symptoms we experience are actually our immune response rather than the virus itself. I could type out, but nah, I can't type out way too much work maybe later sometime will get some.


Edited on 2/27/2020 at 9:41 PM. Reason: fixed link in quote
Ko
#32 (permalink)      2/27/2020 10:11:44 PM US Central   quote/reply + tips
ericbnc
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here is the article

A 10-year-old Connecticut boy died of flu. So did a 21-year-old bodybuilder, and 4-year-old Jonah Reiben of Dayton, Ohio.

These are not the usual sick and elderly people who die from influenza. But every year, flu carries away perfectly healthy young adults and children, and tens of thousands of people over 65.

Doctors who study the body’s immune response say there are three main reasons: co-infection with another germ, usually bacteria such as strep; aggravation of existing conditions such as heart disease and asthma; and a so-called cytokine storm, marked by an overwhelming immune system response to infection.


Sometimes this can happen very fast. During the 1918 “Spanish flu” pandemic that killed up to 50 million people a century ago, many people were reported to have died within hours of showing their first symptoms.

Researchers who have gone back and re-examined tissue samples, and read reports from the time, believe most deaths were caused by co-infection with another germ. But many of the healthy young men and women who died quickly of flu that year more likely succumbed to cytokine storms.

The human immune system has a load of weapons to throw out against infections, including cytokines produced by a variety of immune system cells.

“Those substances work to stop the virus from spreading,” said Dr. Amesh Adalja, an infectious disease specialist and senior scholar at the Johns Hopkins University Center for Health Security.

They cause the typical “flu-like symptoms” that bring misery from flu and other infections.

“The muscle aches, the fever — all of that is the result of the immune system responding to the virus,” Adalja said. That’s why so many diseases cause similar symptoms: it’s the body’s response, not the particular invader, that’s to blame.

But different people have differently composed immune systems.

“In certain individuals there can be a very pronounced immune response that can result in a lot of damage to the cells in your body including the cells in the respiratory tract," Adalja said.

When a virus is new, like the 1918 strain of H1N1 and the 2009 H1N1 “swine flu”, it usually kills far more people. One theory is that the immune system can become overwhelmed by the never-before-seen invader and sends so many troops to fight it that perfectly healthy tissue in the lungs and other organs gets killed, too.

People who die from “bird flu” viruses, such as H5N1 or H7N9, also seem to die via an over-the-top immune response.

And these newer viruses also tend to kill younger people, perhaps because the older population may have been exposed to a distant relative of the virus in the past. The H1N1 flu virus killed 282 U.S. children in 2009-2010, the Centers for Disease Control and Prevention says. It may have infected 61 million people.

Now it’s just part of the annual flu mix and while it is circulating and killing some people this year, it’s the H3N2 strain that is suspected of causing most problems this time around.

After mystery coronavirus case in California, health officials go into detective mode
One experiment showed that certain “new” genes in these never-before-seen viruses help them thrive deep in the lungs, which can cause pneumonia and might provoke an overwhelming immune response.

While a few people seem to die within hours or days, flu can cause lingering sickness in others. Then they become susceptible to other infections, such as streptococcal or staphylococcal bacterial infections.
Up shit creek with a turd for a paddle
#33 (permalink)      2/27/2020 10:13:54 PM US Central   quote/reply + tips
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etcetera
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Whoa, did you type that out?? I couldn't highlight, was sure it was one of those locked articles.

Good job anyway. It is very interesting and informative.
Ko
#34 (permalink)      2/27/2020 10:17:02 PM US Central   quote/reply + tips
ericbnc
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These secondary infections can damage organs, cause pneumonia or get into the bloodstream, causing another kind of immune system overreaction called sepsis.

So far this season, flu has killed 30 children, according to the latest CDC data. Last season, 110 children died from influenza in the U.S.

The CDC doesn’t precisely count adult flu deaths, in no small part because it just kills so many. Every year, flu kills 12,000 to 56,000 people and sends as many as 700,000 to the hospital.

CDC estimates flu deaths by looking at how many more people than usual died of flu and pneumonia, but even those calculations miss people who may have died from flu complications, such as a heart attack set off by a bout of flu.

For patients with asthma or other lung conditions, flu is just one more problem for the lungs to cope with.

“They are already having breathing difficulties. It can put them into a spiral very quickly where their breathing gets compromised,” Adalja said.

Patients with diabetes already have a damaged immune response, so they also are more susceptible to flu.

And pregnant women have a double risk. “Pregnant women are in a state of immunosuppression because the immune system is trying not to reject the fetus,” said Adalja. So the virus can get further, faster in their bodies.

Plus their lungs are compressed by the fetus, so they have less breathing capacity. Humans need a certain level of oxygen and if blood oxygen levels fall too far, they enter a state called hypoxia. Hypoxia can cause organ damage within minutes.

That’s why bluish skin or difficulty breathing is an emergency that requires immediate medical care.

The best defense against flu, the CDC, FDA, pediatricians and other health experts agree, is a flu vaccine. Just about everyone over the age of 6 months should get one and it's still not to late to do it.

And flu is spread by droplets that can linger on surfaces such as countertops, which is why hand-washing is so important. It also spreads via sneezing and coughing and, perhaps, may float in the air on tiny droplets emitted by simple breathing.
Up shit creek with a turd for a paddle
#35 (permalink)      2/28/2020 7:48:17 AM US Central   quote/reply + tips
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Scientists here in Australia, suggest everyone here will, (at some time). catch this COVID-19, sooner' or later'. It's here to stay! Just as the many other strains of Corona Virus has proved to linger for multiple decades. This new strain Virus will further Mutate, with every victim, which make defence impossible.

Have you ever had the Flu? This is the same, COVID-19, only comes with more punch.........

This strain will be just the same as any older Corona classes, e.g , Cold or Flu Virus, however, this strain will impact to more frequent subjects, 50 times easier and harder. than previous efforts of containing it.

This information comes from Australia, And the Government is down-playing the truth, while updating defence programs for isolating and quarantine of such suspected outbreaks.
"The Stand was the Best', however this next series comes 60%, of that of Stephen Kings Movie.

#LegitClassicMovies #CMC #coronaviris
Pandemic | and 2. (Follow thread)

Part 1

Part 2

Do you trust the Government?
I saw the Prick Trump LAUGHING about this epidemic, suggesting to wash hands etc. WHAT a GRUB........... This is exactly what we need to wipe out 40% of our friends.

As on a nasty note, I would love it to gain hold in North Korea, then Kim get's it first. I would love for all of Korea to live in peace and harmony with each other.
I also guess, that's what Korea wishes also/?

Now the assassination squads are on my path,

Edited on 2/28/2020 at 8:25 AM. Reason:
#36 (permalink)      2/28/2020 7:56:52 AM US Central   quote/reply + tips
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Still.Me wrote:

Don't hold me to this but my understanding is that with a virus in general it takes time for ones body to build antibodies. I believe some with this virus don't have time for them to build so through nausea they dehydrate. ( with worst case scenarios of course)Therefore kidney failure is most likely the outcome when that happens.Of course some might still recover for if it is an Acute kidney injury they have a better chance of regaining most of their function again in a normal scenario and/or can be kept alive with dialysis. But if that were commonly happening in an outbreak I think it would be best to use ones best efforts to help those that aren't struck as poorly.



This Virus is different......
Every time it makes transit to another "cell", it mutates into something different.

That's what the Aussie scientists are saying, and they need to find a Vaccine to stop it form entering other cells of our body. eg. Initial mutation.

Secondary infections are now common and more deadly.

Our immune system copies the nastiest of the virus and learns how to kill it.
Secondary infections are always fatal.

COVID-!9......... (The money maker of the 20th Century).




Edited on 2/28/2020 at 8:15 AM. Reason:
#37 (permalink)      2/28/2020 9:38:46 AM US Central   quote/reply + tips
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What a smart doctor this shit4more is.
#38 (permalink)      2/28/2020 1:28:40 PM US Central   quote/reply + tips
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etcetera
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SS' post inspired me to look up various things which I love when it turns up interesting information which it did. I changed the term nCoV in the first quote to covid-19 which the name of the coronavirus was later changed to. This search in particular was trying to ferret out the significance of using IV for coronavirus patients and at least most had some interesting information in regards to IV fluid.

*(SARI = severe acute respiratory infection)

Give supplemental oxygen therapy immediately to patients with SARI and respiratory distress, hypoxaemia, or shock. Remarks: Initiate oxygen therapy at 5 L/min and titrate flow rates to reach target SpO2≥90% in non-pregnant adults and SpO2≥92-95% in pregnant patients. 1, 2 Children with emergency signs (obstructed or absent breathing, severe respiratory distress, central cyanosis, shock, coma or convulsions) should receive oxygen therapy during resuscitation to target SpO2≥94%; otherwise, the target SpO2is ≥90%. 4 All areas where patients with SARI are cared for should be equipped with pulse oximeters, functioning oxygen systems and disposable, single-use, oxygen-delivering interfaces (nasal cannula, simple face mask, and mask with reservoir bag). Use contact precautions when handling contaminated oxygen interfaces of patients with COVID-19 infection.

Use conservative fluid management in patients with SARI when there is no evidence of shock. Remarks: Patients with SARI should be treated cautiously with intravenous fluids, because aggressive fluid resuscitation may worsen oxygenation, especially in settings where there is limited availability of mechanical ventilation.1

https://www.who.int/docs/default-source/coronaviruse/clinical-management-of-novel-cov.pdf

One study being done at the Guangzhou Eighth People's Hospital in China is testing Kaletra against Arbidol, an antiviral drug approved in China and Russia to treat the flu. Two groups of patients will take the medications along with standard care. A third group in the study will receive only standard care, typically supportive therapy with oxygen and IV fluids that are meant to support the body so the immune system can fight off a virus on its own.

https://www.medscape.com/viewarticle/925402

New research calls into question what’s in those IV bags that nearly every hospitalized patient gets. Using a different intravenous fluid instead of the usual saline greatly reduced the risk of death or kidney damage, two large studies found.

The difference could mean 50,000 to 70,000 fewer deaths and 100,000 fewer cases of kidney failure each year in the U.S., researchers estimate. Some doctors are hoping the results will persuade more hospitals to switch.

“We’ve been sounding the alarm for 20 years” about possible harms from saline, said Dr. John Kellum, a critical care specialist at the University of Pittsburgh. “It’s purely inertia” that prevents a change, he said.

The studies involved 28,000 patients at Vanderbilt University who were given IVs of saline or a balanced fluid. For every 100 people on balanced fluids, there was one fewer death or severe kidney problem.

https://www.statnews.com/2018/02/27/iv-bag-saline-patients-hospitals/

In milder cases, patients struggling to maintain blood pressure can be given an intravenous drip. Fluids can also be given in cases of diarrhoea, and ibuprofen is also available for pain relief.
*see notes on cayenne

https://www.bbc.com/news/world-asia-china-51295415

Cayenne tea (or extract) Sorry, no excerpts, just for reference:

https://proliberty.com/observer//20030419.htm
https://en.wikipedia.org/wiki/John_Christopher_(herbalist)
http://www.bastis.org/cayenne.php

Edited on 2/28/2020 at 1:46 PM. Reason: links, highlighting changes
Ko
#39 (permalink)      2/28/2020 1:34:23 PM US Central   quote/reply + tips
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etcetera
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Liver and kidneys

When liver cells are inflamed or damaged, they can leak higher than normal amounts of enzymes into the bloodstream.

Elevated liver enzymes aren’t always a sign of a serious problem, but this laboratory finding was seen in people with SARS or MERS

One recent report found signs of liver damage in a person with COVID-19. Doctors says it’s not clear, though, if the virus or the drugs being used to treat the person caused the damage.

Some people hospitalized with COVID-19 have also had acute kidney damage, sometimes requiring a kidney transplant. This also occurred with SARS and MERS.

During the SARS outbreak, scientists even found the virus that causes this illness in the tubules of the kidneys.

There’s “little evidence,” though, to show that the virus directly caused the kidney injury, according to a World Health Organization report.

Dr. James Cherry, a research professor of pediatrics in the David Geffen School of Medicine at UCLA, says the kidney damage may be due to other changes that happen during coronavirus infection.

“When you have pneumonia, you have less oxygen circulating,” he said, “and that can damage the kidneys.”

Immune system

With any infection, the body’s immune system responds by attacking the foreign virus or bacteria. While this immune response can rid the body of the infection, it can also sometimes cause collateral damage in the body.

This can come in the form of an intense inflammatory response, sometimes called a “cytokine storm.” The immune cells produce cytokines to fight infection, but if too many are released, it can cause problems in the body.

“A lot of [the damage in the body during COVID-19] is due to what we would call a sepsis syndrome, which is due to complex immune reactions,” Evans said. “The infection itself can generate an intense inflammatory response in the body that can affect the function of multiple organ systems.”

Another thing about the immune system is that, so far, there are almost no cases of COVID-19 in children under 9 years old. Scientists aren’t sure whether young children aren’t getting infected or their symptoms are so mild that no one notices it.

Cherry says children also have a less severe illness than adults during other kinds of infections, including measles and pneumococcal infections.

He says this may be because children have a “straightforward immune response,” whereas older people can sometimes have an “over-response.” It’s this excess immune response that causes some of the damage during infections.

“There was evidence of this happening during SARS,” Cherry said, “and I suspect it could also be playing out here [with COVID-19].”

https://www.healthline.com/health-news/heres-what-happens-to-the-body-after-contracting-the-coronavirus#Immune-system

Edited on 2/28/2020 at 2:27 PM. Reason: removed "trusted source" a copy tag-along
Ko
#40 (permalink)      2/28/2020 4:03:16 PM US Central   quote/reply + tips
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Some people hospitalized with COVID-19 have also had acute kidney damage, sometimes requiring a kidney transplant.




To be honest, I find that a bit difficult to believe.
Most people wait years and years for a kidney transplant so i am not sure I believe they are handing them out freely to COVID patients?!

They have managed to speed it up a bit the last couple of years, using kidneys from people that have had HEP C upon their death.
That they can now cure it with drugs in 3 months, allows another avenue of donation, but even then, people still wait a very long time.

To accuse requires less eloquence than to excuse, such is man's nature, it more "resembles" justice
#41 (permalink)      2/28/2020 5:51:55 PM US Central   quote/reply + tips
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etcetera
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I agree it's preposterous. Here is one person who had a kidney transplant 12 years ago and survived COVID-19.

Edited on 2/28/2020 at 5:52 PM. Reason: neglected to add the 12 years ago detail meant to though
Ko